Effect of Aspirin on Platelet 5-Hydroxytryptamine and Beta-Thromboglobulin Plasma Levels in Patients with Myeloproliferative Diseases

Summary

14 patients with myeloproliferative diseases (MD) showed low 5-hydroxytryptamine (5-HT) platelet content and high beta-thromboglobulin (β-TG) plasma levels.

This pattern could support the view that MD platelets undergo “in vivo“ degranulation.

A single dose of aspirin was unable to induce modification of platelet 5-HT and plasma β-TG, whereas 6 out of 14 patients

No modification of platelet 5-HT was obtained suggesting that the cause of dense bodies deficiency may lie in the production of abnormal platelets and not be related to “in vivo” degranulation.

Keywords

Platelets - Myeloproliferative diseases - Beta-thromboglobulin - 5-hydroxytryptamine - Aspirin

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